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Abstract Interband cascade lasers (ICLs) based on the type-II quantum well (QW) active region have attracted much attention for a range of practical applications in the mid-infrared due, in part, to their low power consumption. However, extending the operating wavelength of these ICLs into the long-wave infrared region presents several challenges including the reduced thermal conductivity of the optical cladding layers and the diminished wavefunction overlap in the type-II QW. One solution to alleviate the former concern is to use InAs-based ICLs. To solve the latter problem, InAs 0.5 P 0.5 barriers are introduced in the active region, which lowers the electronic energy level and allows for the InAs well width to be reduced at longer emission wavelengths. Here the advancement of long wavelength ICLs, made from four new InAs-based ICL wafers grown by molecular beam epitaxy, is reported. These ICLs lased in the wavelength range from 10 to 13 µ m and showed significantly improved performance compared with previous ICLs, including the first demonstration of broad-area devices operating in continuous wave mode beyond 12 µ m. These ICLs exhibited substantially increased output powers with reduced threshold voltages ( V th ) and current densities ( J th ). They operated at temperatures up to 40 K higher than previous ICLs at similar wavelengths. 

ABSTRACT Transgenesis is an essential technique for any genetic model. Tol2-based transgenesis paired with Gateway-compatible vector collections has transformed zebrafish transgenesis with an accessible modular system. Here, we establish several next-generation transgenesis tools for zebrafish and other species to expand and enhance transgenic applications. To facilitate gene regulatory element testing, we generated Gateway middle entry vectors harboring the small mouse beta-globin minimal promoter coupled to several fluorophores, CreERT2 and Gal4. To extend the color spectrum for transgenic applications, we established middle entry vectors encoding the bright, blue-fluorescent protein mCerulean and mApple as an alternative red fluorophore. We present a series of p2A peptide-based 3′ vectors with different fluorophores and subcellular localizations to co-label cells expressing proteins of interest. Finally, we established Tol2 destination vectors carrying the zebrafish exorh promoter driving different fluorophores as a pineal gland-specific transgenesis marker that is active before hatching and through adulthood. exorh-based reporters and transgenesis markers also drive specific pineal gland expression in the eye-less cavefish (Astyanax). Together, our vectors provide versatile reagents for transgenesis applications in zebrafish, cavefish and other models. 

We demonstrate an extremely nonlinear all-dielectric metasurface that employs intersubband polaritons to achieve a second-harmonic conversion coefficient of 3 mW/W², and second-harmonic power conversion efficiency of 0.045% at a modest pump intensity of 6.7 kW/cm².